Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls.

ABSTRACT:

Background

Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins.

Objectives

We investigated associations of concurrent exposures from three chemical classes (phenols, phthalates, and phytoestrogens) with pubertal stages in a multiethnic longitudinal study of 1,151 girls from New York City, New York, greater Cincinnati, Ohio, and northern California who were 6-8 years of age at enrollment (2004-2007).

Methods

We measured urinary exposure biomarkers at visit 1 and examined associations with breast and pubic hair development (present or absent, assessed 1 year later) using multivariate adjusted prevalence ratios (PR) and 95% confidence intervals (CIs). Modification of biomarker ass

SUBMITTER: Wolff MS 

PROVIDER: S-EPMC2920905 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature