Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity.

ABSTRACT:

Objective

Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients. The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain.

Methods

Resting-state functional magnetic resonance imaging (FMRI) data from 18 patients with FM and 18 age-matched healthy control subjects were analyzed using dual-regression independent components analysis, which is a data-driven approach for the identification of independent brain networks. Intrinsic, or resting-state, co

SUBMITTER: Napadow V 

PROVIDER: S-EPMC2921024 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature