Dataset Information
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
Ontology highlight
ABSTRACT:
SUBMITTER: Petukhova L
PROVIDER: S-EPMC2921172 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
Nature 20100701 7302
Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P <or= 5 x 10(-7)). Here we show an association with ...[more]
