RLIP76: a target for kidney cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Singhal SS
PROVIDER: S-EPMC2921230 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
RLIP76: a target for kidney cancer therapy.
Singhal Sharad S SS Singhal Jyotsana J Yadav Sushma S Sahu Mukesh M Awasthi Yogesh C YC Awasthi Sanjay S
Cancer research 20090505 10
RLIP76 is a multifunctional transporter protein that serves as an energy-dependent efflux mechanism for endogenously generated toxic metabolites as well as exogenous toxins, including chemotherapy drugs. Our recent studies in cultured cells, syngeneic animal tumor model, and in xenograft model have shown that RLIP76 serves a major cancer-specific antiapoptotic role in a wide variety of histologic types of cancer, including leukemia, melanoma, colon, lung, prostate, and ovarian cancer. Results of ...[more]
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