Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.

ABSTRACT:

Background

The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes.

Aim

To attempt to reproduce these findings, determine the specificity of this signature to CFS/ME, and test for associations between CFS/ME subtype and infection.

Methods

Expression levels of 88 human genes were determined in blood of 62 new patients with idiopathic CFS/ME (according to Fukuda criteria), six patients with Q-fever-associated CFS/ME from the Birmingham Q-fever outbreak (according to Fukuda criteria), 14 patients with endogenous depression (according to DSM-IV criteria) and 29 normal blood donors.

Results

In patients with CFS/ME, differential expression was confirmed for all 88 genes

SUBMITTER: Zhang L 

PROVIDER: S-EPMC2921262 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature