Identifying subjects who benefit from additional information for better prediction of the outcome variables.

ABSTRACT: Suppose that we are interested in using new bio- or clinical markers, in addition to the conventional markers, to improve prediction or diagnosis of the patient's clinical outcome. The incremental value from the new markers is typically assessed by averaging across patients in the entire study population. However, when measuring the new markers is costly or invasive, an overall improvement does not justify measuring the new markers in all patients. A more practical strategy is to utilize the patient's conventional markers to decide whether the new markers are needed for improving prediction of his/her health outcomes. In this article, we propose inference procedures for the incremental values of new markers across various subgroups of patients classified by the conventional markers. The re

SUBMITTER: Tian L 

PROVIDER: S-EPMC2921328 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature