Mab-31 and the TGF-beta pathway act in the ray lineage to pattern C. elegans male sensory rays.

ABSTRACT:

Background

C. elegans TGF-beta-like Sma/Mab signaling pathway regulates both body size and sensory ray patterning. Most of the components in this pathway were initially identified by genetic screens based on the small body phenotype, and many of these mutants display sensory ray patterning defect. At the cellular level, little is known about how and where these components work although ray structural cell has been implicated as one of the targets. Based on the specific ray patterning abnormality, we aim to identify by RNAi approach additional components that function specifically in the ray lineage to elucidate the regulatory role of TGF-beta signaling in ray differentiation.

Result

We report here the characterization of a new member of the Sma/Mab pathway, mab-31, recovered

SUBMITTER: Wong YF 

PROVIDER: S-EPMC2921377 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature