Expression of the transcription factor, TFII-I, during post-implantation mouse embryonic development.

ABSTRACT:

Background

General transcription factor (TFII-I) is a multi-functional transcription factor encoded by the Gtf2i gene, that has been demonstrated to regulate transcription of genes critical for development. Because of the broad range of genes regulated by TFII-I as well as its potential role in a significant neuro-developmental disorder, developing a comprehensive expression profile is critical to the study of this transcription factor. We sought to define the timing and pattern of expression of TFII-I in post-implantation embryos at a time during which many putative TFII-I target genes are expressed.

Findings

Antibodies to the N-terminus of TFII-I were used to probe embryonic mouse sections. TFII-I protein is widely expressed in the developing embryo. TFII-I is expressed th

SUBMITTER: Fijalkowska I 

PROVIDER: S-EPMC2921380 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature