Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection.

Objectives

We hypothesized that airway epithelial cells from patients with COPD maintain a proinflammatory phenotype compared with control subjects, leading to greater RV responses.

Methods

Cells were isolated from tracheobronchial tissues of 12 patients with COPD and 10 transplant donors. Eight patients with COPD had severe emphysema, three had mild to moderate emphysema, and one had no emphysema. All had moderate to severe airflow obstruction, and six met criteria for chronic bronchitis or had at least one exacerbation the previous year. Cells were grown at air-liquid interface and infected with RV s

SUBMITTER: Schneider D 

PROVIDER: S-EPMC2921598 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature