Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial.

ABSTRACT:

Rationale

Hyperglycemia and insulin resistance have been shown to increase morbidity and mortality in severely burned patients, and glycemic control appears essential to improve clinical outcomes. However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality.

Objectives

To determine whether intensive insulin therapy is associated with improved post-burn morbidity.

Methods

A total of 239 severely burned pediatric patients with burns over greater than 30% of their total body surface area were randomized (block randomization 1:3) to intensive insulin treatment (n = 60) or control (n = 179).

Measurements and main results

Demographics, clinical outcomes, sepsis,

SUBMITTER: Jeschke MG 

PROVIDER: S-EPMC2921599 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature