Ontology highlight
ABSTRACT:
SUBMITTER: Saxena R
PROVIDER: S-EPMC2922003 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20100117 2
Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreas ...[more]