Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis.

ABSTRACT:

Background

Recent studies point to a great diversity of non-ribosomal peptide synthesis systems with major roles in amino acid and co-factor biosynthesis, secondary metabolism, and post-translational modifications of proteins by peptide tags. The least studied of these systems are those utilizing tRNAs or aminoacyl-tRNA synthetases (AAtRS) in non-ribosomal peptide ligation.

Results

Here we describe novel examples of AAtRS related proteins that are likely to be involved in the synthesis of widely distributed peptide-derived metabolites. Using sensitive sequence profile methods we show that the cyclodipeptide synthases (CDPSs) are members of the HUP class of Rossmannoid domains and are likely to be highly derived versions of the class-I AAtRS catalytic domains. We also identif

SUBMITTER: Aravind L 

PROVIDER: S-EPMC2922099 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature