Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch.

ABSTRACT:

Background

Herpes simplex virus type 2 (HSV-2) is one of many viruses that exploits and modifies the cellular ubiquitin system. HSV-2 expresses the tegument protein UL56 that has been implicated in cytoplasmic transport and/or release of virions, and is a putative regulatory protein of Nedd4 ubiquitin ligase. In order to elucidate the biological function of UL56, this study examined the interaction of UL56 with the Nedd4-family ubiquitin ligase Itch and its role in the regulation of Itch. Additionally, we assessed the similarity between UL56 and regulatory proteins of Itch and Nedd4, Nedd4-family-interactins proteins (Ndfip).

Results

UL56 interacted with Itch, independent of additional viral proteins, and mediated more striking degradation of Itch, compared to Nedd4. Moreove

SUBMITTER: Ushijima Y 

PROVIDER: S-EPMC2922189 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature