Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1.

ABSTRACT: Regulation of apoptosis and cell cycle progression plays an essential role in the maintenance of B-cell homeostasis, because a fine balance of survival and expansion is critical for preventing lymphocytic disorders. Although remarkable progress in understanding B-cell development has been achieved, much less is known concerning niches that are critical to the maintenance of B-cell homeostasis. Leptin has recently been recognized to be important for modulating the immune responses, but it has remained unclear how leptin signaling influences B-cell physiology. A variety of lymphocytic malignancies have been reported to be linked to leptin, and therefore it is necessary to elucidate the mechanisms involved. Here we demonstrate that leptin promotes B-cell homeostasis by inhibiting apoptosis an

SUBMITTER: Lam QL 

PROVIDER: S-EPMC2922219 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature