Recovery of functional and structural age-related changes in the rat primary auditory cortex with operant training.

ABSTRACT: Cognitive decline is a virtually universal aspect of the aging process. However, its neurophysiological basis remains poorly understood. We describe here more than 20 age-related cortical processing deficits in the primary auditory cortex of aging versus young rats that appear to be strongly contributed to by altered cortical inhibition. Consistent with these changes, we recorded in old rats a decrease in parvalbumin-labeled inhibitory cortical neurons. Furthermore, old rats were slower to master a simple behavior, with learning progressions marked by more false-positive responses. We then examined the effect of intensive auditory training on the primary auditory cortex in these aged rats by using an oddball discrimination task. Following training, we found a nearly complete reversal of th

SUBMITTER: de Villers-Sidani E 

PROVIDER: S-EPMC2922281 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature