Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.

ABSTRACT:

Background

The emergence of drug resistance is a major problem in malaria control. Combination of molecular genotyping and characterization of mutations or single nucleotide polymorphisms (SNPs) correlated with drug resistance can provide information for subsequent surveillance of existing and developing drug resistance patterns. The introduction of artemether/lumefantrine (AL) as first-line treatment, never used before in Ethiopia, allowed the collection of baseline data of molecular polymorphisms before a selection due to AL could occur.

Method

97 patients with uncomplicated falciparum malaria were recruited from April to June 2006 and treated with either AL, quinine (Q) or atovaquone/proguanil (AP) in Jimma University Hospital, Ethiopia. Mutations or SNPs associated with

SUBMITTER: Eshetu T 

PROVIDER: S-EPMC2922303 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature