Phages have adapted the same protein fold to fulfill multiple functions in virion assembly.

ABSTRACT: Evolutionary relationships may exist among very diverse groups of proteins even though they perform different functions and display little sequence similarity. The tailed bacteriophages present a uniquely amenable system for identifying such groups because of their huge diversity yet conserved genome structures. In this work, we used structural, functional, and genomic context comparisons to conclude that the head-tail connector protein and tail tube protein of bacteriophage lambda diverged from a common ancestral protein. Further comparisons of tertiary and quaternary structures indicate that the baseplate hub and tail terminator proteins of bacteriophage may also be part of this same family. We propose that all of these proteins evolved from a single ancestral tail tube protein fold, and

SUBMITTER: Cardarelli L 

PROVIDER: S-EPMC2922521 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature