Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

ABSTRACT: Effective antiviral agents are difficult to develop because of the close relationship between the cell biology of the virus and host. However, viral capsid maturation, the in vivo process where the particle transitions from a noninfectious provirion to an infectious virion, is an ideal process to interrupt because the provirion is usually fragile and the conversion to the virion often involves large conformational changes and autocatalytic chemistry that can be hampered by small molecules. The Nudaurelia capensis omega virus (N omegaV) is one of the few eukaryotic viruses where this process can be investigated in vitro with a variety of biophysical methods, allowing fundamental chemical and structural principles of the maturation to be established. It has a T = 4 quasi-equivalent capsid wi

SUBMITTER: Matsui T 

PROVIDER: S-EPMC2922577 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature