Mining metabolic pathways through gene expression.

ABSTRACT:

Motivation

An observed metabolic response is the result of the coordinated activation and interaction between multiple genetic pathways. However, the complex structure of metabolism has meant that a compete understanding of which pathways are required to produce an observed metabolic response is not fully understood. In this article, we propose an approach that can identify the genetic pathways which dictate the response of metabolic network to specific experimental conditions.

Results

Our approach is a combination of probabilistic models for pathway ranking, clustering and classification. First, we use a non-parametric pathway extraction method to identify the most highly correlated paths through the metabolic network. We then extract the defining structure within these top

SUBMITTER: Hancock T 

PROVIDER: S-EPMC2922890 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature