Genetic ancestry in lung-function predictions.

ABSTRACT:

Background

Self-identified race or ethnic group is used to determine normal reference standards in the prediction of pulmonary function. We conducted a study to determine whether the genetically determined percentage of African ancestry is associated with lung function and whether its use could improve predictions of lung function among persons who identified themselves as African American.

Methods

We assessed the ancestry of 777 participants self-identified as African American in the Coronary Artery Risk Development in Young Adults (CARDIA) study and evaluated the relation between pulmonary function and ancestry by means of linear regression. We performed similar analyses of data for two independent cohorts of subjects identifying themselves as African American: 813 partici

SUBMITTER: Kumar R 

PROVIDER: S-EPMC2922981 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature