Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom.

ABSTRACT:

Background

Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk.

Methods

We report nevus phenotype in relation to differing patterns of sun exposure, inherited variation at loci shown in recent genome-wide association studies to be nevus genes, and risk.

Results

Increased numbers of nevi were associated with holiday sun exposure, particularly on intermittently sun-exposed body sites (test for P(trend) < 0.0001). Large nevi were also associated with holiday sun exposure (P = 0.002). Single nucleotide polymorphisms (SNP) on chromosomes 9 and 22 were associated with increased numbers of nev

SUBMITTER: Newton-Bishop JA 

PROVIDER: S-EPMC2923062 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature