Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.

ABSTRACT:

Background and purpose

Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Methods

Using 2.2 million genotyped and imputed single nucleotide polymorphisms, each study performed cross-sectional genome-wide association analysis of MRI infarct using age- and sex-adjusted logistic regression models. Study-specific findings were combined in an inverse-variance-weighted meta-analysis, including 940

SUBMITTER: Debette S 

PROVIDER: S-EPMC2923092 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature