The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.

ABSTRACT: Since the cloning of the first membrane transporter, our understanding of the role of transporters in clinical drug disposition and response has grown enormously. In parallel, large-scale genome-wide variation studies and the emerging field of pharmacogenomics have ushered in a new understanding of variations in drug response. At the crossroads of pharmacogenomics and transporter biology is the National Institutes of Health-funded Pharmacogenomics of Membrane Transporters (PMT) project, centered at the University of California, San Francisco.

SUBMITTER: Kroetz DL 

PROVIDER: S-EPMC2923224 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature