Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins.

ABSTRACT:

Background

The ferlin gene family possesses a rare and identifying feature consisting of multiple tandem C2 domains and a C-terminal transmembrane domain. Much currently remains unknown about the fundamental function of this gene family, however, mutations in its two most well-characterised members, dysferlin and otoferlin, have been implicated in human disease. The availability of genome sequences from a wide range of species makes it possible to explore the evolution of the ferlin family, providing contextual insight into characteristic features that define the ferlin gene family in its present form in humans.

Results

Ferlin genes were detected from all species of representative phyla, with two ferlin subgroups partitioned within the ferlin phylogenetic tree based on the p

SUBMITTER: Lek A 

PROVIDER: S-EPMC2923515 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature