Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei.

ABSTRACT: The defined shape and single-copy organelles of Trypanosoma brucei mean that it provides an excellent model in which to study how duplication and segregation of organelles is interfaced with morphogenesis of overall cell shape and form. The centriole or basal body of eukaryotic cells is often seen to be at the centre of such processes. We have used a combination of electron microscopy and electron tomography techniques to provide a detailed three-dimensional view of duplication of the basal body in trypanosomes. We show that the basal body duplication and maturation cycle exerts an influence on the intimately associated flagellar pocket membrane system that is the portal for secretion and uptake from this cell. At the start of the cell cycle, a probasal body is positioned anterior to the b

SUBMITTER: Lacomble S 

PROVIDER: S-EPMC2923567 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature