Inferring geographic coordinates of origin for Europeans using small panels of ancestry informative markers.

ABSTRACT: Recent large-scale studies of European populations have demonstrated the existence of population genetic structure within Europe and the potential to accurately infer individual ancestry when information from hundreds of thousands of genetic markers is used. In fact, when genomewide genetic variation of European populations is projected down to a two-dimensional Principal Components Analysis plot, a surprising correlation with actual geographic coordinates of self-reported ancestry has been reported. This substructure can hamper the search of susceptibility genes for common complex disorders leading to spurious correlations. The identification of genetic markers that can correct for population stratification becomes therefore of paramount importance. Analyzing 1,200 individuals from 11 pop

SUBMITTER: Drineas P 

PROVIDER: S-EPMC2923600 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature