Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study.

ABSTRACT:

Background

The Abelson helper integration-1 (AHI1) gene is required for both cerebellar and cortical development in humans. While the accelerated evolution of AHI1 in the human lineage indicates a role in cognitive (dys)function, a linkage scan in large pedigrees identified AHI1 as a positional candidate for schizophrenia. To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany.

Methodology/principal findings

29 single-nucleotide polymorphisms (SNPs) located in a genomic region including the AHI1 gene were genotyped in two samples from Spain (280 patients with psychotic disorders; 348 controls) and Germany (247 patients with schizo

SUBMITTER: Rivero O 

PROVIDER: S-EPMC2923617 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature