LRCH proteins: a novel family of cytoskeletal regulators.

ABSTRACT:

Background

Comparative genomics has revealed an unexpected level of conservation for gene products across the evolution of animal species. However, the molecular function of only a few proteins has been investigated experimentally, and the role of many animal proteins still remains unknown. Here we report the characterization of a novel family of evolutionary conserved proteins, which display specific features of cytoskeletal scaffolding proteins, referred to as LRCHs.

Principal findings

Taking advantage of the existence of a single LRCH gene in flies, dLRCH, we explored its function in cultured cells, and show that dLRCH act to stabilize the cell cortex during cell division. dLRCH depletion leads to ectopic cortical blebs and alters positioning of the mitotic spindle. We fu

SUBMITTER: Foussard H 

PROVIDER: S-EPMC2923620 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature