Evolution and molecular epidemiology of subtype C HIV-1 in Zimbabwe.

ABSTRACT:

Objective

To investigate the origins and evolutionary history of subtype C HIV-1 in Zimbabwe in a context of regional conflict and migration.

Design

HIV-1C pol sequence datasets were generated from four sequential cohorts of antenatal women in Harare, Zimbabwe sampled over 15 years (1991-2006).

Methods

One hundred and seventy-seven HIV-1C pol sequences were obtained from four successive cohorts in Zimbabwe. Maximum-likelihood methods were used to explore phylogenetic relationships between Zimbabwean HIV-1C sequences and subtype C strains from other regions. A Bayesian coalescent-based framework was used to estimate evolutionary parameters for HIV-1C in Zimbabwe, including origin and demographic growth patterns.

Results

Zimbabwe HIV-1C pol demonstrated increasin

SUBMITTER: Dalai SC 

PROVIDER: S-EPMC2923658 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature