Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease.

ABSTRACT:

Purpose

To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD.

Materials and methods

The study was conducted with institutional review board approval and in compliance with HIPAA regulations. Written informed consent was obtained from each participant or participant's legal guardian. Fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging data were analyzed from 80 healthy control (HC) subjects, 68 individuals with AD, and 156 with amnestic mild cognitive impairment (MCI), 69 of whom had single-domain amnestic MCI. Regions of interest (ROIs) were derived aft

SUBMITTER: Karow DS 

PROVIDER: S-EPMC2923729 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature