Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling.

ABSTRACT: The genome of mantle cell lymphoma (MCL) is, in addition to the translocation t(11;14), characterized by a high number of secondary chromosomal gains and losses that probably account for the various survival times of MCL patients. We investigated 77 primary MCL tumors with available clinical information using high-resolution RNA expression and genomic profiling and applied our recently developed gene expression and dosage integrator algorithm to identify novel genes and pathways that may be of relevance for the pathobiology of MCL. We show that copy number neutral loss of heterozygosity is common in MCL and targets regions that are frequently affected by deletions. The molecular consequences of genomic copy number changes appear complex, even in genomic loci with identified tumor suppresso

SUBMITTER: Hartmann EM 

PROVIDER: S-EPMC2924229 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature