Systematic analysis of short internal indels and their impact on protein folding.

ABSTRACT:

Background

Protein sequence insertions/deletions (indels) can be introduced during evolution or through alternative splicing (AS). Alternative splicing is an important biological phenomenon and is considered as the major means of expanding structural and functional diversity in eukaryotes. Knowledge of the structural changes due to indels is critical to our understanding of the evolution of protein structure and function. In addition, it can help us probe the evolution of alternative splicing and the diversity of functional isoforms. However, little is known about the effects of indels, in particular the ones involving core secondary structures, on the folding of protein structures. The long term goal of our study is to accurately predict the protein AS isoform structures. As a fir

SUBMITTER: Kim R 

PROVIDER: S-EPMC2924343 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature