Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans.

ABSTRACT: Three closely related bacterial species within the genus Neisseria are of importance to human disease and health. Neisseria meningitidis is a major cause of meningitis, while Neisseria gonorrhoeae is the agent of the sexually transmitted disease gonorrhea and Neisseria lactamica is a common, harmless commensal of children. Comparative genomics have yet to yield clear insights into which factors dictate the unique host-parasite relationships exhibited by each since, as a group, they display remarkable conservation at the levels of nucleotide sequence, gene content and synteny. Here, we discovered two rare alterations in the gene encoding the CcoP protein component of cytochrome cbb(3) oxidase that are phylogenetically informative. One is a single nucleotide polymorphism resulting in CcoP tr

SUBMITTER: Aspholm M 

PROVIDER: S-EPMC2924362 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature