Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of cancer death. Changes in apoptosis signaling in pancreatic cancer result in chemotherapy resistance and aggressive growth and metastasizing. The aim of this study was to characterize the apoptosis pathway in pancreatic cancer computationally by evaluation of experimental data from high-throughput technologies and public data bases. Therefore, gene expression analysis of microdissected pancreatic tumor tissue was implemented in a model of the apoptosis pathway obtained by computational protein interaction prediction.

Methodology/principal findings

Apoptosis pathway related genes were assembled from electronic databases. To assess expression of these genes we constructed a virtual subarray from a

SUBMITTER: Ruckert F 

PROVIDER: S-EPMC2924379 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature