Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.

ABSTRACT: Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African-American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose A

SUBMITTER: Fushan AA 

PROVIDER: S-EPMC2924427 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature