Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial.

ABSTRACT:

Objective

To study rates of relapse in remitted patients with first episode psychosis who either continued or discontinued antipsychotic drugs after at least one year of maintenance treatment.

Design

12 month randomised, double blind, placebo controlled trial.

Setting

Early psychosis outpatient clinics in Hong Kong.

Participants

178 patients with first episode psychosis who had received at least one year of antipsychotic drug treatment between September 2003 and July 2006 and had no positive symptoms of psychosis.

Interventions

Patients received either maintenance treatment with quetiapine (400 mg/day) or placebo and were followed up for the next 12 months or until a relapse occurred.

Main outcome measure

Relapse assessed monthly and defined as re

SUBMITTER: Chen EY 

PROVIDER: S-EPMC2924475 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature