Expanding the question-answering potential of single-cell microbeams at RARAF, USA.

ABSTRACT: Charged-particle microbeams, developed to provide targeted irradiation of individual cells, and then of sub-cellular components, and then of 3-D tissues and now organisms, have been instrumental in challenging and changing long accepted paradigms of radiation action. However the potential of these valuable tools can be enhanced by integrating additional components with the direct ability to measure biological responses in real time, or to manipulate the cell, tissue or organism of interest under conditions where information gained can be optimized. The RARAF microbeam has recently undergone an accelerator upgrade, and been modified to allow for multiple microbeam irradiation laboratories. Researchers with divergent interests have expressed desires for particular modalities to be made avail

SUBMITTER: Bigelow A 

PROVIDER: S-EPMC2924733 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature