Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC2924742 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20091001 8
Understanding of heterogeneous NK subsets is important for the study of NK cell biology and development, and for the application of NK cell-based therapies in the treatment of disease. Here we demonstrate that the surface expression of CD94 can distinctively divide mouse NK cells into two approximately even CD94(low) and CD94(high) subsets in all tested organs and tissues. The CD94(high) NK subset has significantly greater capacity to proliferate, produce IFN-gamma, and lyse target cells than do ...[more]