MUC5AC expression in human middle ear epithelium of patients with otitis media.

ABSTRACT:

Objective

To compare levels of middle ear (ME) MUC5AC expression in patients with otitis media (OM) with patients without OM. Mucin gene 5AC has been identified as a major secretory mucin in the ME and is fundamentally important in the development of ME mucoid effusions, hearing loss and also provides ME mucosal protection and bacterial clearance.

Design

Case control.

Setting

Tertiary, academic, pediatric otolaryngology practice.

Patients

Patients 9 months to 7 years old undergoing routine tympanostomy tube (TT) insertion for recurrent otitis media (RecOM) or chronic otitis media with effusion (COME) were compared with control patients without a history of OM undergoing cochlear implantation.

Methods

During routine TT placement or cochlear implantation,

SUBMITTER: Kerschner JE 

PROVIDER: S-EPMC2924762 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature