Lymphoma in patients treated with anti-TNF: results of the 3-year prospective French RATIO registry.

ABSTRACT:

Objective

To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare the risks for different anti-TNF agents.

Methods

A national prospective registry was designed (Research Axed on Tolerance of bIOtherapies; RATIO) to collect all cases of lymphoma in French patients receiving anti-TNF therapy from 2004 to 2006, whatever the indication. A case-control analysis was conducted including two controls treated with anti-TNF per case and an incidence study of lymphoma with the French population was used as the reference.

Results

38 cases of lymphoma, 31 non-Hodgkin's lymphoma (NHL) (26 B cell and five T cell), five Hodgkin's lymphoma (HL) and two Hodgkin's-like lymphoma were collected. Epstein-Barr virus was detec

SUBMITTER: Mariette X 

PROVIDER: S-EPMC2925048 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature