Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib.

ABSTRACT:

Background

Observational studies have shown reduced risk of Alzheimer dementia in users of nonsteroidal anti-inflammatory drugs.

Objective

To evaluate the effects of naproxen sodium and celecoxib on cognitive function in older adults.

Design

Randomized, double-masked chemoprevention trial.

Setting

Six US memory clinics.

Participants

Men and women aged 70 years and older with a family history of Alzheimer disease; 2117 of 2528 enrolled had follow-up cognitive assessment.

Interventions

Celecoxib (200 mg twice daily), naproxen sodium (220 mg twice daily), or placebo, randomly allocated in a ratio of 1:1:1.5, respectively.

Main outcome measures

Seven tests of cognitive function and a global summary score measured annually.

Results

Longit

SUBMITTER: ADAPT Research Group 

PROVIDER: S-EPMC2925195 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature