Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes.

ABSTRACT:

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Recent advances in induced pluripotent stem (iPS) cell research have significantly changed our perspective on regenerative medicine. Patient-specific iPS cells have been derived not only for disease modeling but also as sources for cell replacement therapy. However, there have been insufficient data to prove that iPS cells are functionally equivalent to human embryonic stem (hES) cells or are safer than hES cells. There are several important issues that need to be addressed, and foremost are the safety and efficacy of human iPS cells of different origins. Human iPS cells have been derived mostly from cells originating from mesoderm and in a few cases from ectoderm. So far, there has been no report of endoderm-derived human iPS cells, and this has prevented comprehensive

SUBMITTER: Liu H 

PROVIDER: S-EPMC2925460 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature