Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.

ABSTRACT:

Objective

The association between obesity and breast cancer risk is complex. We examined whether the association between body size and breast cancer risk is modified by interleukin-6 (IL6) genotype.

Methods and procedures

Five polymorphisms in the IL-6 gene (rs1800797/-596A>G, rs1800796/-572G>C, rs1800795/-174G>C, rs2069832/IVS2G>A, and rs2069849 exon 5 C>T) were studied. We investigated IL6 genotypes and haplotypes with indicators of body size among non-Hispanic white (NHW) and Hispanic/American Indian (AI) breast cancer cases and controls living in the Southwestern United States.

Results

We observed lower mean levels of BMI among NHW women who carried one or two copies of the GGCAC haplotype (in order: rs1800797, rs1800796, rs1800795, rs2069832, and rs2069849; P tre

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC2925502 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature