Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes.

ABSTRACT:

Background

Long considered to be the building block of life, it is now apparent that protein is only one of many functional products generated by the eukaryotic genome. Indeed, more of the human genome is transcribed into noncoding sequence than into protein-coding sequence. Nevertheless, whilst we have developed a deep understanding of the relationships between evolutionary constraint and function for protein-coding sequence, little is known about these relationships for non-coding transcribed sequence. This dearth of information is partially attributable to a lack of established non-protein-coding RNA (ncRNA) orthologs among birds and mammals within sequence and expression databases.

Results

Here, we performed a multi-disciplinary study of four highly conserved and brain-e

SUBMITTER: Chodroff RA 

PROVIDER: S-EPMC2926783 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature