Quantifying the mechanisms of domain gain in animal proteins.

ABSTRACT:

Background

Protein domains are protein regions that are shared among different proteins and are frequently functionally and structurally independent from the rest of the protein. Novel domain combinations have a major role in evolutionary innovation. However, the relative contributions of the different molecular mechanisms that underlie domain gains in animals are still unknown. By using animal gene phylogenies we were able to identify a set of high confidence domain gain events and by looking at their coding DNA investigate the causative mechanisms.

Results

Here we show that the major mechanism for gains of new domains in metazoan proteins is likely to be gene fusion through joining of exons from adjacent genes, possibly mediated by non-allelic homologous recombination. Ret

SUBMITTER: Buljan M 

PROVIDER: S-EPMC2926785 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature