Paternally biased X inactivation in mouse neonatal brain.

ABSTRACT:

Background

X inactivation in female eutherian mammals has long been considered to occur at random in embryonic and postnatal tissues. Methods for scoring allele-specific differential expression with a high degree of accuracy have recently motivated a quantitative reassessment of the randomness of X inactivation.

Results

After RNA-seq data revealed what appeared to be a chromosome-wide bias toward under-expression of paternal alleles in mouse tissue, we applied pyrosequencing to mouse brain cDNA samples from reciprocal cross F1 progeny of divergent strains and found a small but consistent and highly statistically significant excess tendency to under-express the paternal X chromosome.

Conclusions

The bias toward paternal X inactivation is reminiscent of marsupials (and

SUBMITTER: Wang X 

PROVIDER: S-EPMC2926790 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature