Fpr3 and Zip3 ensure that initiation of meiotic recombination precedes chromosome synapsis in budding yeast.

ABSTRACT:

Background

Homolog pairing, synaptonemal complex (SC) assembly (chromosome synapsis), and crossover recombination are essential for successful meiotic chromosome segregation. A distinguishing feature of meiosis in budding yeast and mammals is that synapsis between homologs depends upon recombination; however, the molecular basis for this contingency is not understood.

Results

We show here that the yeast proline isomerase Fpr3 and the small ubiquitin-like modifier (SUMO) ligase Zip3 ensure that SC assembly is dependent upon recombination initiation. When Fpr3 and Zip3 are absent, synapsis occurs even in a mutant that fails to initiate recombination and homolog pairing. Fpr3 and Zip3 appear to specifically prevent synapsis initiation at centromeric sites. This result is consis

SUBMITTER: Macqueen AJ 

PROVIDER: S-EPMC2926792 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature