Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration.

ABSTRACT: It is well-established that neurons in the adult mammalian central nervous system (CNS) are terminally differentiated and, if injured, will be unable to regenerate their connections. In contrast to mammals, zebrafish and other teleosts display a robust neuroregenerative response. Following optic nerve crush (ONX), retinal ganglion cells (RGC) regrow their axons to synapse with topographically correct targets in the optic tectum, such that vision is restored in approximately 21 days. What accounts for these differences between teleostean and mammalian responses to neural injury is not fully understood. A time course analysis of global gene expression patterns in the zebrafish eye after ONX can help to elucidate cellular and molecular mechanisms that contribute to a successful neuroregenerat

SUBMITTER: McCurley AT 

PROVIDER: S-EPMC2926816 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature