Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice.

ABSTRACT:

Background

Changes in lifestyle have resulted in an epidemic development of obesity-related diseases that challenge the healthcare systems worldwide. To develop strategies to tackle this problem the focus is on diet to prevent the development of obesity-associated diseases such as cardiovascular disease (CVD). This will require methods for linking nutrient intake with specific metabolic processes in different tissues.

Methodology/principal finding

Low-density lipoprotein receptor-deficient (Ldlr -/-) mice were fed a high fat/high sugar diet to mimic a westernized diet, being a major reason for development of obesity and atherosclerosis. The diets were supplemented with either beef or herring, and matched in macronutrient contents. Body composition, plasma lipids and aortic l

SUBMITTER: Nookaew I 

PROVIDER: S-EPMC2927425 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature