Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas.

ABSTRACT:

Background

Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the predicted target genes in ULMs and matched myometria.

Methodology/principal findings

Patterns of inverse association of microRNA with mRNA expression in ULMs revealed an involvement of multiple candidate pathways, including extensive transcriptional reprogramming, cell proliferation control, MAP kinase, TGF-beta, WNT, JAK/STAT signaling, remodeling of cell adhesion, and cell-cell and cell-matrix contacts. We further examined the correlation between the expression of the se

SUBMITTER: Zavadil J 

PROVIDER: S-EPMC2927438 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature